Doctor's Formulas D-Mannose 60 Capsules

Formula D - Mannose is a dietary supplement that contains the monosaccharide D-mannose.

What is D-Mannose?
D-mannose is a simple sugar, which has a special contribution to metabolism, through its role in the glycosylation of certain proteins.
D-mannose is rapidly absorbed and reaches the peripheral organs in about 30 minutes and is then excreted from the urinary tract.
It cannot be converted into glycogen, therefore, it is not stored in the body.
It attaches to lectins and thus prevents the adhesion of pathogens to the walls of the bladder.

Mechanism of Action
Its mechanism of action is expressed through inhibition of the attachment of the surface protein FimH. By the direct binding of FimH to D-mannose bound to a carrier protein, which is responsible for receptor specificity.
The 1st stage of adhesion involves the mannose-sensitive attachment of FimH to the epithelium. The bladder wall is coated with various proteins glycated with mannose, such as the Tamm-Horsfall protein (THP) which directly interferes with the adhesion of microbes to the mucosa.
The Tamm-Horsfall protein (TIR) can bind to E. Coli with a special bond, which can be inhibited by exogenous D-mannose.
By inhibiting the adhesion of microbes to the urinary tract epithelium, D-mannose mimics the function of the urinary tract epithelial barrier.